Virtue explores the vulnerability and randomness of human existence through the lives of Tom and Hannah Holder, each of whom are grappling with midlife crises. Hannah is sick of being a stay-at-home mom marooned in a rural college town, her teenage daughter, Madison, is the subject of anti-LGBTQ bullying, and her teenage son, Dillon, is failing at school and having run-ins with the law. Her husband Tom, a philosophy professor, once supported her plea for change—a return to Boston that would give their kids a fresh start and her the chance to finally finish her law degree—but now his life is unraveling as he struggles to fend off attacks on his career from the college president, reconcile with his estranged, cancer-stricken father and confront a dark, hidden past.