Six strangers arrive at the home of preeminent puzzle master Alexei Vasiliev for the reading of his will. Among them are the deceased's widow, who'd already begun divorce proceedings, a virologist troubled by actions in his past, and a convicted murderer on day release. The potential beneficiaries will split Vasiliev's $150M fortune if they participate in his last great work.

The choice is simple: leave the house with nothing or continue in the hope of solving the six interconnecting escape rooms within this house.

Once there, the participants soon discover Puzzle House is far deadlier than it appears, and that making their way through the rooms may be a matter of life and death. Someone is watching their every move, toying with them, turning them against each other. With their lives on the line, they are forced to wonder, is it all just a deadly game created by a gleeful sadist, or something far more sinister?