From her office in Manhattan, Hadley is preparing for her twenty-second wedding anniversary. She surprises her husband, Bergen, with a gift to get their genomes sequenced to proactively counter any disease risks.

In the East Village, twenty-seven-year-old Rachel reluctantly goes to therapy for her panic attacks and flashbacks from a college rape. Her mother is overprotective, and her father has left the family.

When the genome results come back, Hadley learns her fate and spirals into depression. Her family struggles to help while grieving her mental decline.

Rachel and Hadley meet in the therapist's waiting room. One woman is desperately holding onto her memories, while the other tries to banish them. They form a supportive friendship, each filling a void in the other's life. As their bond strengthens, both struggle with suicidal ideations, threatening their progress.