The Great Healthcare Disruption
Big Tech, Bold Policy, and the Future of American Medicine
by Marschall Runge
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Pub Date May 06 2025 | Archive Date May 06 2025
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Description
Discover the innovations transforming medicine—and the fight to make care more equitable, accessible, and effective.
In The Great Healthcare Disruption, Dr. Marschall Runge—cardiologist, researcher, and CEO of Michigan Medicine—offers a gripping, insider’s look at the forces rapidly reshaping American healthcare. From artificial intelligence and retail medicine to revolutionary gene therapies and next-generation obesity drugs, this is your essential guide to the most significant transformation in medical care since the discovery of antibiotics.
Inside you’ll explore:
- The rise of Big Tech in medicine—how Amazon, Google, and other disruptors are redefining the patient experience
- Breakthrough treatments and AI-driven diagnostics reshaping chronic disease management, behavioral health, and drug development
- The hidden trade-offs of innovation—how cutting-edge care delivery models are improving outcomes while straining the systems meant to support them
- Why traditional institutions must evolve—and how academic medical centers can remain vital in a tech-driven world
- Hard truths about access, equity, and affordability—and what must change to make healthcare work for everyone
With rich storytelling, sharp insights, and practical solutions, Dr. Runge cuts through the complexity of modern medicine to offer a bold, balanced path forward.
Whether you're a healthcare professional, policy leader, or curious reader, The Great Healthcare Disruption is your guide to understanding—and shaping—the revolution already underway.
Featured Reviews

Just like I’m wildly impressed that Dr. Runge somehow manages to be the executive vice president for Medical Affairs at the University of Michigan, dean of the Medical School, **and** CEO of Michigan Medicine, I’m very impressed with this book.
Appreciated the wide yet focused snapshot of where healthcare is right now and where it is likely going next. While I was familiar with many of these topics, I felt I still learned something in each chapter. Some are lighter than others, reflecting a comparative lack of definitive knowledge in that given area.
As a medical student, I suspect that if we raise PCPs to the level of gatekeeper that this book recommends we would have to dramatically cut down on patient census numbers - PCPs I rotated with were absolutely inundated on EMRs with tasks they can’t directly bill for. The idea of PCPs being aware of all care a patient seeks is an interesting one - but I question the legal liability and mental workload this places on an already overloaded medical segment.
I also very much appreciate the fact that it feels like there is little to no filler content in this book. Every fact and figure is meaningful.
Excited to read his medical thriller next!
Thank you to NetGalley and Forbes Books for the advanced reader copy.
Notable Quotes: “Ultimately healthcare spending isn’t merely a cost; it’s an investment. Understanding these nuanced truths requires patience, context, and willingness to look beyond simplistic headlines. When we focus only on price tags, we lose sight of what federal investments in healthcare have achieved: industries sparked by public research funding, biotech revolutions, and countless lives improved by prevention and innovation.”
“Most of all, we’ll identify and assess what’s next for healthcare—an industry that’s undergoing significant, deeply transformative disruption and yet, at its core, remains centered around the care that one human being provides to another.”